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Transcriptional Signatures of Field Cancerization in Gastric Cancer

2025-09-21

Abstract excerpt

The high rate of local recurrence in gastric adenocarcinoma (GA) suggests that carcinogenesis is not a focal event but a field-wide process. This phenomenon, known as “field cancerization,” posits that histologically normal peritumoral tissue is, in fact, a pre-neoplastic field harboring incipient molecular alterations that confound genomic studies using it as a normal control. To overcome this limitation, we perf...

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Literature Corpus work
a83a2009-7508-55b2-92d4-7d7c34963677
DOI
10.1101/2025.09.15.676327
Open publication

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Transcriptional Signatures of Field Cancerization in Gastric CancerDOI 10.1101/2025.09.15.676327
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