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Article

Epigenetic inactivation of FAT4 contributes to gastric field cancerization.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Jan 2017

Yoshida Satoshi, Yamashita Satoshi, Niwa Tohru, Mori Akiko, Ito Seiji, Ichinose Masao, Ushijima Toshikazu

Abstract excerpt

BACKGROUND: Gastric cancer (GC) is highly influenced by aberrant methylation, and accumulation of aberrant methylation in gastric mucosae produces an epigenetic field for cancerization. Nevertheless, the individual driver genes involved in such field cancerization are still unclear. Here, we aimed to demonstrate that FAT4, a novel tumor suppressor identified by exome sequencing of GC, is methylation-silenced and...

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Identifiers

PMID: 26792292
DOI: 10.1007/s10120-016-0593-5

Genes

FAT4

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