Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical molecular subtyping reveals intrinsic mesenchymal reprogramming in gastric cancer cells

1 May 2023

Abstract excerpt

The mesenchymal cancer phenotype is known to be clinically related to treatment resistance and a poor prognosis. We identified gene signature-based molecular subtypes of gastric cancer (GC, n = 547) based on transcriptome data and validated their prognostic and predictive utility in multiple external cohorts. We subsequently examined their associations with tumor microenvironment (TME) features by employing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37121972
DOI: 10.1038/s12276-023-00989-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical molecular subtyping reveals intrinsic mesenchymal reprogramming in gastric cancer cellsPMID 37121972Read ↗

Parallel single-cell and bulk transcriptome analyses reveal key features of the gastric tumor microenvironmentSemantic proximity Read ↗

Single-Cell Genomic Characterization Reveals the Cellular Reprogramming of the Gastric Tumor MicroenvironmentSemantic proximity Read ↗

Single cell genomic characterization reveals the cellular reprogramming of the gastric tumor microenvironmentSemantic proximity Read ↗

Integrative single-cell and spatial transcriptomics uncover ELK4-mediated mechanisms in NDUFAB1+ tumor cells driving gastric cancer progression, metabolic reprogramming, and immune evasionSemantic proximity Read ↗

Gastric Cancer Tumor Immune Microenvironment Landscape: Clinical Implications for Patient Outcome and Response to PD-1 Immune Checkpoint BlockadeSemantic proximity Read ↗

Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype.Semantic proximity Read ↗

Deciphering of intra‐tumoural heterogeneity and the interplay between metastasis‐associated meta‐program and myofibroblasts in gastric cancerSemantic proximity Read ↗

Spatial dissection of cellular heterogeneity and functional crosstalk in the tumor microenvironments of gastric cancersSemantic proximity Read ↗

Molecular and Structural Reprogramming of Gastric Cancer Revealed by Systems-Level Transcriptomic AnalysisSemantic proximity Read ↗

A Dynamic Transcriptome Map of Different Tissue Microenvironment Cells Identified During Gastric Cancer Development Using Single-Cell RNA Sequencing.Semantic proximity Read ↗

Representing ECM composition and EMT pathways in gastric cancer using a new metastatic gene signatureSemantic proximity Read ↗

A Stromal-Immune Gene Signature for Precision Prognosis and Therapeutic Guidance in Gastric CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.