Continuous high-resolution <i>in vivo</i> imaging reveals tumor-specific dissemination in an embryonic zebrafish xenograft model

Abstract excerpt

Mechanisms mediating tumor metastasis are crucial for diagnostic and therapeutic targeting. Here, we take advantage of a transparent embryonic zebrafish xenograft model (eZXM) to visualize and track injected human leukemic and breast cancer cells in real time using selective plane illumination microscopy (SPIM) for up to 30 hours. Injected cells exhibited disease-specific patterns of intravascular distribution wit...

Topics

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• Cell Movement
• Disease Progression
• Imaging, Three-Dimensional
• Neoplasm Invasiveness
• rho GTP-Binding Proteins
• Vascular Endothelial Growth Factor A
• Xenograft Model Antitumor Assays
• Zebrafish

Identifiers and source

Literature Corpus work

a83514d2-42a5-5365-9a48-b38f53f61d24

DOI

10.1101/215921