Developing a zebrafish xenograft model of diffuse midline glioma

Abstract excerpt

Diffuse midline glioma (DMG) is a highly aggressive brain tumor that predominantly affects children. Conventional treatments such as radiation therapy can control progression for a time, but DMG kills nearly 100 percent of patients. Although murine models have provided critical insights into the biology of DMG and in assessing new therapeutic strategies, they are not suitable for high-throughput screening to ident...

Topics

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• Anesthesia and Neurotoxicity Research
• Animals, Genetically Modified
• Cancer, Hypoxia, and Metabolism
• Gene Editing
• Glioma Diagnosis and Treatment
• High-Throughput Screening Assays
• Single-cell and spatial transcriptomics
• Zebrafish Biomedical Research Applications

Identifiers and source

Literature Corpus work

2be908a0-bb96-55c2-ab64-10a266e7a8a8

DOI

10.1101/2025.03.31.646163