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Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis

20 Jun 2024

Abstract excerpt

The mechanism by which chondrocyte senescence aggravate OA progression has not yet been well elucidated. The aim of this study was to investigate the chondrocyte senescence related gene biosignatures in OA, and to analyze on the underlying mechanisms of senescence in OA. We intersected osteoarthritis dataset GSE82107 from GEO database and senescence dataset from CellAge database of human senescence-associated...

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Bone Metabolism and Diseases
Connective Tissue Growth Factor Research
Osteoarthritis Treatment and Mechanisms

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39007035
DOI: 10.1016/j.jot.2024.06.008

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