Article

Transcriptomic changes during the replicative senescence of human articular chondrocytes

2023-11-07

Abstract excerpt

Osteoarthritis (OA) is a degenerative joint disease and a leading cause of disability worldwide. Aging is a major risk factor for OA, but the specific mechanisms underlying this connection remain unclear. Although chondrocytes rarely divide in adult articular cartilage, they undergo replicative senescence in vitro which provides an opportunity to study changes related to aging under controlled laboratory conditio...

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Literature Corpus work: 99f72221-9591-501a-a1a3-38b792105cf2
DOI: 10.1101/2023.11.07.565835

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