Article

Targeting mTOR restores tau-induced metabolic, mitochondrial, and cognitive deficits in a tauopathy mouse model

2024-11-24

Abstract excerpt

<h4>Aim</h4> Hyperphosphorylated tau is a hallmark of Alzheimer’s disease (AD). However, whether mammalian target of rapamycin (mTOR) directly regulates tau phosphorylation at Ser214, Ser356, and Thr231 and how such regulation affects mitochondrial function remain unclear. In this study, we aimed to determine whether mTOR-mediated tau phosphorylation disrupts mitochondrial and metabolic profiles and cognitive fun...

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Literature Corpus work: a819fc12-a28b-5bd2-99c8-e37112c438af
DOI: 10.1101/2024.11.24.625068

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