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Article

mTOR inhibition enhances synaptic and mitochondrial function in Alzheimer's disease in an APOE genotype-dependent manner.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Oct 2024

Sanganahalli Basavaraju G, Mihailovic Jelena M, Vekaria Hemendra J, Coman Daniel, Yackzan Andrew T, Flemister Abeoseh, Aware Chetan, Wenger Kathryn, Hubbard W Brad, Sullivan Patrick G, Hyder Fahmeed, Lin Ai-Ling

Abstract excerpt

Apolipoprotein ε4 (APOE4) carriers develop brain metabolic dysfunctions decades before the onset of Alzheimer's disease (AD). A goal of the study is to identify if rapamycin, an inhibitor for the mammalian target of rapamycin (mTOR) inhibitor, would enhance synaptic and mitochondrial function in asymptomatic mice with human APOE4 gene (E4FAD) before they showed metabolic deficits. A second goal is to determine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38879800
DOI: 10.1177/0271678X241261942
PMCID: PMC11494852

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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