Article
HER family in cancer progression: From discovery to 2020 and beyond.
Advances in cancer research - 1 Jan 2020
Kumar Rakesh, George Bijesh, Campbell Marcia R, Verma Nandini, Paul Aswathy Mary, Melo-Alvim Cecília, Ribeiro Leonor, Pillai M Radhakrishna, da Costa Luis Marques, Moasser Mark M
Abstract excerpt
The human epidermal growth factor receptor (HER) family of receptor tyrosine kinases (RTKs) are among the first layer of molecules that receive, interpret, and transduce signals leading to distinct cancer cell phenotypes. Since the discovery of the tooth-lid factor-later characterized as the epidermal growth factor (EGF)-and its high-affinity binding EGF receptor, HER kinases have emerged as one of the commonly...
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