Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanisms of receptor tyrosine kinase activation in cancer.

Molecular cancer - 19 Feb 2018

Du Zhenfang, Lovly Christine M

Abstract excerpt

Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK signaling leads to an assortment of human diseases, most notably, cancers. Recent large-scale genomic studies have revealed the presence of various alterations in the genes encoding RTKs such as EGFR, HER2/ErbB2, and MET, amongst many...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Enzyme Activation
Share to Ligands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Targeted Therapy

Share to Protein Interaction Domains and Motifs

Share to Protein Kinase Inhibitors

Share to Protein Multimerization

Share to Receptor Protein-Tyrosine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 29455648
DOI: 10.1186/s12943-018-0782-4
PMCID: PMC5817791

Genes

EGFR
MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanisms of receptor tyrosine kinase activation in cancer.PMID 29455648Read ↗

Receptor tyrosine kinases: biological functions and anticancer targeted therapySemantic proximity Read ↗

Roles for receptor tyrosine kinases in tumor progression and implications for cancer treatment.Semantic proximity Read ↗

Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challengesSemantic proximity Read ↗

Receptor Tyrosine Kinase-Targeted Cancer TherapySemantic proximity Read ↗

Receptor tyrosine kinases: from biology to pathology.Semantic proximity Read ↗

Receptor Tyrosine Kinases as Therapeutic Targets the Model of the MET OncogeneSemantic proximity Read ↗

Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addictionSemantic proximity Read ↗

Receptor tyrosine kinases as targets for anticancer drugs.Semantic proximity Read ↗

To Investigate Growth Factor Receptor Targets and Generate Cancer Targeting InhibitorsSemantic proximity Read ↗

Genomic alterations of ERBB receptors in cancer: clinical implicationsSemantic proximity Read ↗

TRKing down an old oncogene in a new era of targeted therapy.Semantic proximity Read ↗

HER family in cancer progression: From discovery to 2020 and beyond.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.