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Article

Evaluating p97 Inhibitor Analogues for Potency against p97-p37 and p97-Npl4-Ufd1 Complexes.

ChemMedChem - 6 May 2016

Gui Lin, Zhang Xiaoyi, Li Kelin, Frankowski Kevin J, Li Shan, Wong Daniel E, Moen Derek R, Porubsky Patrick R, Lin Henry J, Schoenen Frank J, Chou Tsui-Fen

Abstract excerpt

We previously found that the p97 cofactor, p47, significantly decreased the potency of some ATP-competitive p97 inhibitors such as ML240 [2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine] and ML241 [2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8 tetrahydroquinazolin-4-amine]. In this study, we aimed to evaluate inhibitor potencies against two additional p97 cofactor complexes,...

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Identifiers

PMID: 27043824
DOI: 10.1002/cmdc.201600036
PMCID: PMC9049307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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