Article

Minimising mutation load as a mechanism for low-dose hyper-radiosensitivity and induced radioresistance

2025-05-16

Abstract excerpt

<title>Abstract</title> <p>Low-dose hyper-radiosensitivity (HRS) and induced radioresistance (IRR) are unexpected features of cellular survival curves that challenge classical radiobiological models. While often interpreted phenomenologically, their underlying biological purpose remains unclear. Here we propose that these effects reflect an evolved strategy by which tissues minimise mutational burden through cont...

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Literature Corpus work: a7cba3b4-accb-5361-b8f5-5d0f48c0b929
DOI: 10.21203/rs.3.rs-6674497/v1

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