Minimising mutation load as a mechanism for low-dose hyper-radiosensitivity and induced radioresistance.

doi:10.1038/s41598-026-65215-y

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Article

Minimising mutation load as a mechanism for low-dose hyper-radiosensitivity and induced radioresistance.

Scientific reports - 25 Aug 2026

Polgár Szabolcs, Madas Balázs G

Abstract excerpt

Low-dose hyper-radiosensitivity (HRS) and induced radioresistance (IRR) are unexpected features of cellular survival curves that challenge classical radiobiological models. While often interpreted phenomenologically, their underlying biological purpose remains unclear. Here we propose that these effects reflect an evolved strategy by which tissues minimise mutational burden through context-dependent cell...

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Identifiers

PMID: 42642455
DOI: 10.1038/s41598-026-65215-y
PMCID: PMC13507289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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