Influence of LET on Low-dose Radiation Responses: Signatures of Hyper-radiosensitivity after High-LET Irradiation.

Abstract excerpt

Hyper-radiosensitivity refers to increased cellular sensitivity at low doses of ionizing radiation and is not accurately captured by classical radiobiological models. While predominantly studied in the context of low-LET radiation, such as photons, its behavior under high-LET conditions remains less well characterized. In this work, we introduce an analytical formulation of the minimum mutation load (MML) model....

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