Article

High complexity cellular barcoding and clonal tracing reveals stochastic and deterministic parameters of radiation resistance

2020-10-16

Abstract excerpt

The impact of functional heterogeneity in response to radiation therapy is poorly understood to the present. It remains elusive whether clonal selection of tumor cells in response to ionizing radiation (IR) is a deterministic or stochastic process. We applied high-resolution lentiviral cellular barcoding for quantitative clonal tracking and deconvolution of clonal dynamics in response to IR. Clonal tracking of ove...

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Literature Corpus work: 362eb52f-8698-5ae4-8f00-8818b79b7810
DOI: 10.1101/2020.10.13.337519

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