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Article

Integrated analysis of ALK higher expression in human cancer and downregulation in LUAD using RNA molecular scissors.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Sept 2022

Saifullah, Tsukahara Toshifumi

Abstract excerpt

PURPOSE: Anaplastic lymphoma kinase (ALK) is an endorsed molecular target in ALK-rearranged carcinomas, including lung adenocarcinoma. However, the clinical advantage of targeting ALK using druggable inhibitors is almost universally restricted by the development of drug resistance. Therefore, a strategy for combating ALK overexpression remains paramount for ALK-driven cancer. METHODS: We systemically analyzed the...

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PMID: 35486222
DOI: 10.1007/s12094-022-02835-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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