Functional cooperation between the B-cell receptor and NOTCH1 in regulating metabolic reprogramming in chronic lymphocytic leukemia.

doi:10.1038/s41375-026-02912-7

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Article

Functional cooperation between the B-cell receptor and NOTCH1 in regulating metabolic reprogramming in chronic lymphocytic leukemia.

Leukemia - 1 May 2026

Fascì Amelia, Vallone Francesco Edoardo, Nabelsi Nahal, Viry Elodie, Sana Ilenia, Morabito Alessia, Seghezzi Silvia, Pesce Noemi Anna, Rovere Matteo, Bertola Nadia, Duculty Chloé, Ravera Silvia, Mouhssine Samir, Muzio Marta, Ghia Paolo, Vitale Candida, Coscia Marta, Moussay Etienne, Gaidano Gianluca, Allan John, Furman Richard R, Paggetti Jerome, Vaisitti Tiziana, Deaglio Silvia

Abstract excerpt

Mutations in NOTCH1, which occur in ~10% of Chronic Lymphocytic Leukemia (CLL) patients at diagnosis, are typically associated with unmutated (UM) B-cell receptor (BCR) subsets and define patients with earlier treatment need. Using primary CLL cells classified as NOTCH1 wild-type (CLL/NWT) or mutated (CLL/NM), both with UM-BCR, we show that BCR stimulation activates the NOTCH1 pathway, upregulating metabolic...

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Identifiers

PMID: 41872504
DOI: 10.1038/s41375-026-02912-7
PMCID: PMC13149317

Genes

NOTCH1
BCR
TFAM
BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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