Article

Chromosome silencing <i>in vitro</i> reveals trisomy 21 causes cell-autonomous deficits in angiogenesis and early dysregulation in Notch signaling

2022-06-01

Abstract excerpt

<h4>SUMMARY</h4> Despite the prevalence and clinical importance of Down syndrome, little is known as to the specific cell pathologies that underlie this multi-system disorder. To understand which cell types and pathways are more directly impacted by trisomy 21, we used an inducible- XIST system to silence the extra chromosome 21 in a panel of patient-derived iPSCs. Transcriptomic analysis showed significant dysr...

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Literature Corpus work: 4ff293c5-5679-5711-8045-7a9dd8773c19
DOI: 10.1101/2022.06.01.494361

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