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Literature review: enteric nervous system development, genetic and epigenetic regulation in the etiology of Hirschsprung's disease

1 Jun 2021

Abstract excerpt

Hirschsprung's disease (HSCR) is a developmental disorder of the enteric nervous system (ENS) derived from neural crest cells (NCCs), which affects their migration, proliferation, differentiation, or preservation in the digestive tract, resulting in aganglionosis in the distal intestine. The regulation of both NCCs and the surrounding environment involves various genes, signaling pathways, transcription factors,...

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PMID: 34195419
DOI: 10.1016/j.heliyon.2021.e07308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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