Article

8-oxoguanine DNA glycosylase1 recognizes oxidatively-generated epitranscriptomic marks on nascent mRNAs to promote RSV replication

2021-05-20

Abstract excerpt

<title>Abstract</title> <p>Respiratory syncytial virus (RSV) infection induces an oxidizing environment linked to increased viral load, expression of pro-inflammatory genes, and excessive lung inflammation. The mechanisms of how reactive oxygen species (ROS) promotes viral gene expression have remained largely elusive. Here we show that nascent (n)RNAs of RSV acquire 8-oxo-7,8-dihydroguanine (8-oxo(r)Gua) -a cova...

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Literature Corpus work: 8f04b10b-8bb5-5266-ae32-c2b6daf30e32
DOI: 10.21203/rs.3.rs-515369/v1

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8-oxoguanine DNA glycosylase1 recognizes oxidatively-generated epitranscriptomic marks on nascent mRNAs to promote RSV replicationDOI 10.21203/rs.3.rs-515369/v1Read

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