Article

HBsAg-induced ROS drives NK cell exhaustion via LAG-3 upregulation and hinders HBeAg seroconversion in CHB

2026-02-05

Abstract excerpt

<title>Abstract</title> <p>Dysfunction of NK cells contributes to immune escape in chronic hepatitis B (CHB), yet the regulatory mechanisms, particularly the interplay between immune checkpoints and oxidative stress, remain incompletely understood. This study analyzed 42 CHB patients and 22 healthy controls, revealing a specific elevation in reactive oxygen species (ROS) levels within peripheral blood NK cells fr...

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Literature Corpus work: a75a1af4-8a31-5fec-b706-bc887e207f60
DOI: 10.21203/rs.3.rs-8677306/v1

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