Article
NK cell phenotypic and functional shifts coincide with specific clinical phases in the natural history of chronic HBV infection.
Antiviral research - 1 Apr 2017
de Groen Rik A, Hou Jun, van Oord Gertine W, Groothuismink Zwier M A, van der Heide Marieke, de Knegt Robert J, Boonstra André
Abstract excerpt
BACKGROUND: Chronic HBV infection can be divided into 4 distinct clinical phases: immune tolerant, immune active, inactive carrier, and HBeAg-negative hepatitis. Using a systems biology approach, we recently identified innate immune response components, specifically NK cells as a distinctive factor of specific HBV clinical phases. To expand on this study and identify the underlying immunological mechanisms, we...
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