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Article

Peripheral NK cell phenotypic alteration and dysfunctional state post hepatitis B subviral particles stimulation in CHB patients: evading immune surveillance.

Frontiers in immunology - 1 Jan 2024

Selim Mohamed A, Suef Reda A, Saied Ebrahim, Abdel-Maksoud Mostafa A, Almutairi Saeedah Musaed, Aufy Mohammed, Mousa Adel A, Mansour Mohamed T M, Farag Mohamed M S

Abstract excerpt

Background: The relationship between chronic hepatitis B (CHB) infection and natural killer (NK) cell dysfunction is well-established, but the specific role of HBV viral antigens in driving NK cell impairment in patients with CHB remains unclear. This study investigates the modulatory effects of hepatitis B virus subviral particles (HBVsvp, a representative model for HBsAg) on the phenotypic regulation...

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Share to Cytotoxicity, Immunologic
Share to Hep G2 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B, Chronic

Share to Hepatitis B Surface Antigens

Share to Hepatitis B virus

Share to Immunologic Surveillance

Share to Killer Cells, Natural

Share to NK Cell Lectin-Like Receptor Subfamily K

Source

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Identifiers

PMID: 39328404
DOI: 10.3389/fimmu.2024.1427519
PMCID: PMC11424423

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