Impaired HBsAg release and antiproliferative/antioxidant cell regulation by HBeAg-negative patient isolates reflects an evolutionary process.

doi:10.1111/liv.16048

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Impaired HBsAg release and antiproliferative/antioxidant cell regulation by HBeAg-negative patient isolates reflects an evolutionary process.

Liver international : official journal of the International Association for the Study of the Liver - 1 Oct 2024

Basic Michael, Thiyagarajah Keerthihan, Glitscher Mirco, Schollmeier Anja, Wu Qingyan, Görgülü Esra, Lembeck Pia, Sonnenberg Jannik, Dietz Julia, Finkelmeier Fabian, Praktiknjo Michael, Trebicka Jonel, Zeuzem Stefan, Sarrazin Christoph, Hildt Eberhard, Peiffer Kai-Henrik

Abstract excerpt

BACKGROUND: The hepatitis B e antigen (HBeAg)-negative infection Phase 3 is characterized by no or minimal signs of hepatic inflammation and the absence of hepatic fibrosis. However, underlying molecular mechanisms leading to this benign phenotype are poorly understood. METHODS: Genotype A, B and D HBeAg-negative patient isolates with precore mutation G1896A from Phase 3 were analysed in comparison with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antioxidants

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Hepatitis B, Chronic

Share to Hepatitis B e Antigens

Share to Hepatitis B Surface Antigens

Share to Hepatitis B virus

Share to NF-E2-Related Factor 2

Share to Virus Replication

Source

Open in PubMed

Identifiers

PMID: 39078064
DOI: 10.1111/liv.16048

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired HBsAg release and antiproliferative/antioxidant cell regulation by HBeAg-negative patient isolates reflects an evolutionary process.PMID 39078064Read ↗

Intracellular accumulation of subviral HBsAg particles and diminished Nrf2 activation in HBV genotype G expressing cells lead to an increased ROI level.Semantic proximity Read ↗

Hepatitis B e Antigen Expression by Hepatitis B Virus Subgenotype A1 Relative to Subgenotypes A2 and D3 in Cultured Hepatocellular Carcinoma (Huh7) Cells.Semantic proximity Read ↗

Transcriptome analysis of hepatoma cells transfected with Basal Core Promoter (BCP) and Pre-Core (PC) mutant hepatitis B virus full genome construct.Semantic proximity Read ↗

Hepatitis B virus escape mutants induced by antiviral therapy.Semantic proximity Read ↗

HBsAg-induced ROS drives NK cell exhaustion via LAG-3 upregulation and hinders HBeAg seroconversion in CHBSemantic proximity Read ↗

Permissive, in vitro replication of hepatitis B virus genotype E.Semantic proximity Read ↗

In vitro studies identify a low replication phenotype for hepatitis B virus genotype H generally associated with occult HBV and less severe liver disease.Semantic proximity Read ↗

HBsAg level defines different clinical phenotypes of HBeAg(-) chronic HBV infection related to HBV polymerase-specific CD8+ cell response quality.Semantic proximity Read ↗

Phenotyping hepatitis B virus variants: from transfection towards a small animal in vivo infection model.Semantic proximity Read ↗

High rates of chronic HBV genotype E infection in a group of migrants in Italy from West Africa: Virological characteristics associated with poor immune clearance.Semantic proximity Read ↗

Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategySemantic proximity Read ↗

Characterization of hepatitis B viral forms from patient plasma using velocity gradient: evidence for an excess of capsids in Dane particles enriched fractionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.