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Article

SIGLEC-3 (CD33) serves as an immune checkpoint receptor for HBV infection.

The Journal of clinical investigation - 1 Jun 2021

Tsai Tsung-Yu, Huang Ming-Ting, Sung Pei-Shan, Peng Cheng-Yuan, Tao Mi-Hua, Yang Hwai-I, Chang Wei-Chiao, Yang An-Suei, Yu Chung-Ming, Lin Ya-Ping, Bau Ching-Yu, Huang Chih-Jen, Pan Mei-Hung, Wu Chung-Yi, Hsiao Chwan-Deng, Yeh Yi-Hung, Duan Shiteng, Paulson James C, Hsieh Shie-Liang

Abstract excerpt

Chronic hepatitis B (CHB) infection is rarely eradicated by current antiviral nucleos(t)ide analogues. We found that α2,6-biantennary sialoglycans of HBV surface antigen (HBsAg) bound human SIGLEC-3 (CD33) by IP and ELISA, and the binding affinity between SIGLEC-3 and α2,6-biantennary sialoglycans was determined by biolayer interferometry (equilibrium dissociation constant [KD]: 1.95 × 10-10 ± 0.21 × 10-10 M)....

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Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepatitis B, Chronic

Share to Hepatitis B Surface Antigens

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Share to Sialic Acid Binding Ig-like Lectin 3

Source

Open in PubMed Open full text

Identifiers

PMID: 34060491
DOI: 10.1172/JCI141965
PMCID: PMC8159688

Genes

CD33
CD14
CD40
CD80
CD86

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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