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Disruptions in Outer Membrane-Peptidoglycan Interactions Enhance Bile Salt Resistance in O-antigen-Producing <i>E. coli</i>

2025-02-10

Abstract excerpt

Bile salts (BS) are derived from cholesterol in the liver and act as antimicrobial agents in the intestines by disrupting bacterial cell membranes and inducing oxidative stress. The gut bacterium E. coli is naturally resistant to BS, including the model strain K12 that produces a truncated LPS without O-antigen (OAg). Paradoxically, restoring a wild-type like LPS with OAg sensitises E. coli K12 to exogenous BS....

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Literature Corpus work
a7557c0b-d0be-539c-9772-0685880d20b4
DOI
10.1101/2025.02.09.637341
Open publication

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Disruptions in Outer Membrane-Peptidoglycan Interactions Enhance Bile Salt Resistance in O-antigen-Producing <i>E. coli</i>DOI 10.1101/2025.02.09.637341
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