Article

Data-driven design of targeted gene panels for estimating immunotherapy biomarkers

2021-03-17

Abstract excerpt

<title>Abstract</title> <p>We introduce a novel data-driven framework for the design of targeted gene panels for estimating exome-wide biomarkers in cancer immunotherapy. Our first goal is to develop a generative model for the profile of mutation across the exome, which allows for gene- and variant type-dependent mutation rates. Based on this model, we then propose a new procedure for estimating biomarkers such a...

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Literature Corpus work: a7106036-133f-596e-895a-f62a1ea72909
DOI: 10.21203/rs.3.rs-223265/v1

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