Article

Probabilistic mixture models improve calibration of panel-derived tumor mutational burden in the context of both tumor-normal and tumor-only sequencing

2022-04-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Tumor mutational burden (TMB) has been investigated as a biomarker for immune checkpoint blockade (ICB) therapy. Increasingly, TMB is being estimated with gene panel-based assays (as opposed to full exome sequencing) and different gene panels cover overlapping but distinct genomic coordinates, making comparisons across panels difficult. Previous studies have suggested that s...

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Literature Corpus work: 45b4f85b-b748-56e2-869c-d0896c6c20af
DOI: 10.1101/2022.04.22.489230

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