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Prospective Germline Exome and Machine Learning-Based Risk Score Identify Predictive and PrognosticBiomarkers of Immunotherapy Outcomes in Advanced Non-Small Cell Lung Cancer

2026-01-20

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape of advanced non-small cell lung cancer (NSCLC). However, a substantial proportion of patients do not experience durable clinical benefits, and established tumour biomarkers, such as PD-L1 expression and tumour mutational burden, often show limited predictive value. The potential of i...

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Literature Corpus work: 3824805a-8ec0-58d1-8a3f-59a92073edc1
DOI: 10.21203/rs.3.rs-8455214/v1

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