Article

Enabling Systemic Identification and Functionality Profiling for Cdc42 Homeostatic Modulators

2024-01-08

Abstract excerpt

Homeostatic modulation is pivotal in modern therapeutics. However, the discovery of bioactive materials to achieve this functionality is often random and unpredictive. Here, we enabled a systemic identification and functional classification of chemicals that elicit homeostatic modulation of signaling through Cdc42, a classical small GTPase of Ras superfamily. Rationally designed for high throughput screening, the...

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Literature Corpus work: a6f6625c-92db-5ac0-b1f9-bb01af8e5905
DOI: 10.1101/2024.01.05.574351

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