Article

Modulation of CIP2A dimerization and protein stability via druggable pocket

2025-10-14

Abstract excerpt

Cancerous inhibitor of PP2A (CIP2A) supports malignant growth across several cancer types. CIP2A is also a synthetic lethal therapy target for BRCA-mutant cancers. In addition, CIP2A causes Alzheimer's disease (AD) phenotype in mice. However, it is not dispensable for normal development and growth. Therefore, CIP2A is very lucrative therapy target in cancer and AD. So far it has been unclear whether the CIP2A prot...

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Identifiers and source

Literature Corpus work: 812a032d-8079-5ad6-afa0-08a2fc10d132
DOI: 10.1101/2025.10.13.682046

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