Article

Shared genetic etiology between chronic diseases and heart failure risk: the dual role of leukocyte telomere length

2023-08-08

Abstract excerpt

<h4>Introduction</h4> Genetic susceptibility to various chronic diseases has been shown to influence heart failure (HF) risk. However, the pathogenic mechanisms underlying these associations, particularly the role of phenotypic leukocyte telomere length (LTL), is unknown. We investigated the shared genetic etiology between chronic diseases, various traits, and HF risk, and whether LTL mediates or modifies these re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a6f22331-b5ed-589d-bb6a-1f0eadbaccea
DOI: 10.1101/2023.08.03.23293621

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Shared genetic etiology between chronic diseases and heart failure risk: the dual role of leukocyte telomere lengthDOI 10.1101/2023.08.03.23293621Read

Genetic susceptibility to chronic diseases leads to heart failure among Europeans: the influence of leukocyte telomere length.Semantic proximity Read

Dissecting the pleiotropic genetic architecture linking telomere biology to chronic respiratory diseases and lung functionSemantic proximity Read

Identifying Potential Causal Effects of Telomere Length on Health Outcomes: A Phenome-Wide Investigation and Mendelian Randomization Study.Semantic proximity Read

Evidence that Telomere Length is Causal for Idiopathic Pulmonary Fibrosis but not Chronic Obstructive Pulmonary Disease: A Mendelian Randomisation StudySemantic proximity Read

Genetically determined telomere length and its association with chronic obstructive pulmonary disease and interstitial lung disease in biobank Japan: A Mendelian randomization studySemantic proximity Read

Polygenic basis and biomedical consequences of telomere length variationSemantic proximity Read

Casual Effects of Telomere Length on Sarcoidosis: A Bidirectional Mendelian Randomisation AnalysisSemantic proximity Read

Breaking down causes, consequences, and mediating effects of telomere length variation on human healthSemantic proximity Read

Shared Genetic Architecture and Causal Relationship Between Asthma and Cardiovascular Diseases: A Large-Scale Cross-Trait AnalysisSemantic proximity Read

Mapping the aetiological foundations of the heart failure spectrum using human geneticsSemantic proximity Read

Heart-lung connections: Phenotypic and genetic insights from a large-scale genome-wide cross-trait analysisSemantic proximity Read