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Article

The probable cell of origin of NF1- and PDGF-driven glioblastomas.

PloS one - 1 Jan 2011

Hambardzumyan Dolores, Cheng Yu-Kang, Haeno Hiroshi, Holland Eric C, Michor Franziska

Abstract excerpt

Primary glioblastomas are subdivided into several molecular subtypes. There is an ongoing debate over the cell of origin for these tumor types where some suggest a progenitor while others argue for a stem cell origin. Even within the same molecular subgroup, and using lineage tracing in mouse models, different groups have reached different conclusions. We addressed this problem from a combined mathematical...

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Identifiers

PMID: 21931722
DOI: 10.1371/journal.pone.0024454
PMCID: PMC3170338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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