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Article

NMDA receptor antagonism and the ethanol intoxication signal: from alcoholism risk to pharmacotherapy.

Annals of the New York Academy of Sciences - 1 Nov 2003

Krystal John H, Petrakis Ismene L, Krupitsky Evgeny, Schutz Christian, Trevisan Louis, D'Souza D Cyril

Abstract excerpt

This paper reviews clinical evidence suggesting that antagonism of the N-methyl-D-aspartate subtype of glutamate receptors by ethanol may convey an important component of the ethanol intoxication signal, that is, subjective and objective responses associated with the consumption of a large amount of ethanol. It will then review recent evidence that two phenotypes associated with increased risk for heavy alcohol...

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Source

Identifiers

PMID: 14684445
DOI: 10.1196/annals.1300.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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