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Article

Pharmacotherapy, pharmacogenomics, and the future of alcohol dependence treatment, part 1

1 Nov 2004

Abstract excerpt

PURPOSE: The neurobiological basis of alcohol dependence, established pharmacotherapies for alcohol dependence, pharmacotherapies under investigation, and obstacles to treatment are discussed. SUMMARY: Alcohol binds to hydrophobic pockets of proteins, changing their three-dimensional structure and their function. Proteins that are particularly sensitive to alcohol include ion channels, neurotransmitter receptors,...

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PMID: 15552634
DOI: 10.1093/ajhp/61.21.2272

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