A Low Tumor Mutational Burden and PTEN Mutations Are Predictors of a Negative Response to PD-1 Blockade in MSI-H/dMMR Gastrointestinal Tumors.

doi:10.1158/1078-0432.CCR-21-0401

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Article

A Low Tumor Mutational Burden and PTEN Mutations Are Predictors of a Negative Response to PD-1 Blockade in MSI-H/dMMR Gastrointestinal Tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2021

Chida Keigo, Kawazoe Akihito, Kawazu Masahito, Suzuki Toshihiro, Nakamura Yoshiaki, Nakatsura Tetsuya, Kuwata Takeshi, Ueno Toshihide, Kuboki Yasutoshi, Kotani Daisuke, Kojima Takashi, Taniguchi Hiroya, Mano Hiroyuki, Ikeda Masafumi, Shitara Kohei, Endo Itaru, Yoshino Takayuki

Abstract excerpt

PURPOSE: This study performed a comprehensive molecular characterization of microsatellite instability-high (MSI-H)/mismatch repair-deficient (dMMR) gastrointestinal (GI) tumors to elucidate predictors of response to PD-1 blockade. EXPERIMENTAL DESIGN: Forty-five patients with MSI-H/dMMR GI tumors, including gastric cancer, colorectal cancer, cholangiocarcinoma, small intestine cancer, pancreatic cancer, and...

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PMID: 33926917
DOI: 10.1158/1078-0432.CCR-21-0401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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