Article

CRISPR/Cas9 knockout and editing of the major cysteine protease in <i>Entamoeba histolytica</i>

2026-06-09

Abstract excerpt

Entamoeba histolytica is the cause of amoebiasis, a diarrheal infection that is a significant source of morbidity and mortality. Despite its importance to human health, the basic mechanism of disease is poorly understood. E. histolytica is dramatically understudied, even in comparison to other understudied parasites, due to challenging features of its genome and the relative paucity of genetic tools. A major limit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a6bbe2b0-54d1-5200-baa7-57d55404e4fd
DOI: 10.64898/2026.06.08.731005

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CRISPR/Cas9 knockout and editing of the major cysteine protease in <i>Entamoeba histolytica</i>DOI 10.64898/2026.06.08.731005Read

CRISPR/Cas9 gene editing in the heterotrophic protist <i>Acanthamoeba castellanii</i>Semantic proximity Read

Major cysteine peptidases of <i>Entamoeba histolytica</i> are required for aggregation and digestion of erythrocytes but are dispensable for phagocytosis and cytopathogenicitySemantic proximity Read

Efficient Genome Engineering of Toxoplasma gondii Using CRISPR/Cas9Semantic proximity Read

Robust and stable transcriptional repression in <i>Giardia</i> using CRISPRiSemantic proximity Read

CRISPR-prime editing, a versatile genetic tool to create specific mutations with a single nucleotide resolution in Leptospira.Semantic proximity Read

Optimizing Systems for Cas9 Expression in Toxoplasma gondiiSemantic proximity Read

Targeted CRISPR screens reveal genes essential for Cryptosporidium survival in the host intestineSemantic proximity Read

Regulation of Virulence of<i>Entamoeba histolytica</i>Semantic proximity Read

Using an Endogenous CRISPR-Cas System for Genome Editing in the Human Pathogen Clostridium difficileSemantic proximity Read

The immune system of prokaryotes: potential applications and implications for gene editingSemantic proximity Read

Cellular and molecular mechanisms that underlie Entamoeba histolytica pathogenesis: prospects for interventionSemantic proximity Read

Recyclable CRISPR/Cas9 mediated gene disruption and deletions in <i>Histoplasma</i>Semantic proximity Read