Major cysteine peptidases of <i>Entamoeba histolytica</i> are required for aggregation and digestion of erythrocytes but are dispensable for phagocytosis and cytopathogenicity

Abstract excerpt

Cysteine peptidases of Entamoeba histolytica (EhCPs) are considered to be important pathogenicity factors. It has been described that under standard axenic culture conditions, only three (ehcp-a1, ehcp-a2 and ehcp-a5) out of approximately 50 cysteine peptidase genes present in the E. histolytica genome are substantially expressed, thus representing the set of major EhCPs. In this study, transcriptional silencing...

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