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Targeted CRISPR screens reveal genes essential for Cryptosporidium survival in the host intestine

20 Aug 2025

Abstract excerpt

The Cryptosporidium parasite is one of the leading causes of diarrheal morbidity and mortality in children, and adolescent infections are associated with chronic malnutrition. There are no vaccines available for protection and only one drug approved for treatment that has limited efficacy. A major barrier to developing new therapeutics is a lack of foundational knowledge of Cryptosporidium biology, including...

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PMID: 40835841
DOI: 10.1038/s41467-025-63012-1

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