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Using an Endogenous CRISPR-Cas System for Genome Editing in the Human Pathogen Clostridium difficile

9 Aug 2019

Abstract excerpt

Clostridium difficile represents today a real danger for human and animal health. It is the leading cause of diarrhea associated with health care in adults in industrialized countries. The incidence of these infections continues to increase, and this trend is accentuated by the general aging of the population. Many questions about the mechanisms contributing to C. difficile 's success inside the host remain...

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PMID: 31399410
DOI: 10.1128/aem.01416-19

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