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In Vivo Bioincubation Promotes Maturation of Human iPSC-Derived Cardiomyocytes in Neonatal Rat and Pig Hearts

2026-07-22

Abstract excerpt

<h4>ABSTRACT</h4> Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) hold great promise for cardiac regenerative medicine and disease modeling. However, hiPSC-CMs generated through conventional in vitro differentiation exhibit immature, fetal-like phenotypes. While in vivo bioincubation in neonatal rodent hearts promotes hiPSC-CM maturation toward adult-like phenotypes, studies in large anim...

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Literature Corpus work
a68baaa1-4a53-52e8-aa7c-c6a3f11fce53
DOI
10.64898/2026.07.21.739858
Open publication

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