Article

<i>In vivo</i> bioreactor matures iPSC-CMs for MLP disease modeling

2025-08-15

Abstract excerpt

Muscle LIM protein (MLP) is a critical regulator of cardiomyocytes (CMs) cytoarchitecture, and its deficiency results in late-onset dilated cardiomyopathy (DCM) in both mice and human. However, recapitulating this phenotype in vitro using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) has been challenging largely due to their immature state. Here, we generated MLP knockout (MLP-KO) mouse iPSCs an...

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Literature Corpus work: a5deaab6-5098-5c19-aca1-e9e7e6fe6a79
DOI: 10.1101/2025.08.11.669708

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