Article

Human iPSC-derived Committed Cardiac Progenitors Generate Cardiac Tissue Grafts in a Swine Ischemic Cardiomyopathy Model without Triggering Ventricular Arrhythmias

2024-02-17

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Intramyocardial injection of human pluripotent stem cell-derived cardiomyocytes following a myocardial infarction (MI) improves cardiac function in large animal models, but associated ventricular arrhythmias are major safety concern. We hypothesized that transendocardial injection of human induced pluripotent stem cell (hiPSC)-derived committed cardiac progenitor cells (CCPs...

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Literature Corpus work: eb948086-8093-54d6-aac2-cbeab3962783
DOI: 10.1101/2024.02.14.580375

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