Article

The Sequence Basis for Selectivity of Ephrin-B2 Ligand for Eph Receptors and Pathogenic Henipavirus G Glycoproteins

2023-04-26

Abstract excerpt

<h4>ABSTRACT</h4> Ephrin-B2 (EFNB2) is a ligand for six Eph receptors in humans and functions as a cell entry receptor for several henipaviruses including Nipah virus (NiV), a pathogenic zoonotic virus with pandemic potential. To understand the sequence basis of promiscuity for EFNB2 binding to the attachment glycoprotein of NiV (NiV-G) and Eph receptors, we performed deep mutagenesis on EFNB2 to identify mutatio...

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Literature Corpus work: 93931987-d400-5e6d-a806-b3218e9d6b44
DOI: 10.1101/2023.04.26.538420

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