Article
Discerning intersecting fusion-activation pathways in the Nipah virus using machine learning.
Proteins - 1 Dec 2014
Varma Sameer, Botlani Mohsen, Leighty Ralph E
Abstract excerpt
The fusion of Nipah with host cells is facilitated by two of their glycoproteins, the G and the F proteins. The binding of cellular ephrins to the G head domain causes the G stalk domain to interact differently with F, which activates F to mediate virus-host fusion. To gain insight into how the ephrin-binding signal transduces from the head to the stalk domain of G, we examine quantitatively the differences...
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