Article

A mutational atlas for Parkin proteostasis

2023-06-08

Abstract excerpt

The delicate balance of protein homeostasis can be disturbed by mutations that affect folding and stability of the encoded protein. More than half of disease-causing missense variants are thought to lead to protein degradation, but determining which and the molecular mechanisms involved remain enigmatic. To examine these issues, we selected the ubiquitin-protein ligase Parkin, where known missense variants result...

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Literature Corpus work: 6752d62e-3156-5b90-ae17-6d1ab60fe2e7
DOI: 10.1101/2023.06.08.544160

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