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Comprehensive Variant Effect Map of Parkin-Mediated Mitophagy in Parkinson’s Disease

2026-02-09

Abstract excerpt

The development of Parkinson’s disease (PD) has a substantial genetic basis. Variants in the PRKN gene account for roughly half of autosomal-recessive PD cases, yet most variants remain classified as variants of uncertain significance. PRKN encodes the E3 ubiquitin-protein ligase, Parkin, that plays a key role in mitochondrial quality control by initiating mitophagy. In this work, we introduce a multiplexed mito...

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Literature Corpus work
6c05b30c-c9c5-5e1e-b37b-2756a1dce683
DOI
10.64898/2026.02.09.704749
Open publication

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Comprehensive Variant Effect Map of Parkin-Mediated Mitophagy in Parkinson’s DiseaseDOI 10.64898/2026.02.09.704749
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