Article

Pharmacological inhibition of the VCP/proteasome axis rescues photoreceptor degeneration in RHO <sup>P23H</sup> rat retinal explants

2021-06-14

Abstract excerpt

1. Rhodopsin ( RHO ) misfolding mutations are a common cause of the blinding disease autosomal dominant retinitis pigmentosa (adRP). The most prevalent mutation, RHO P23H , results in its misfolding and retention in the Endoplasmic Reticulum (ER). Under homeostatic conditions, misfolded proteins are selectively identified, retained at the ER, and cleared via ER-associated degradation (ERAD) and/or autophagy. Ove...

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Literature Corpus work: a65f1623-5e4c-521f-8ec9-c8abacc9ad86
DOI: 10.1101/2021.06.14.448364

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