Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacological clearance of misfolded rhodopsin for the treatment of RHO-associated retinitis pigmentosa.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2020

Liu Xujie, Feng Bing, Vats Abhishek, Tang Hong, Seibel William, Swaroop Manju, Tawa Gregory, Zheng Wei, Byrne Leah, Schurdak Mark, Chen Yuanyuan

Abstract excerpt

Rhodopsin mutation and misfolding is a common cause of autosomal dominant retinitis pigmentosa (RP). Using a luciferase reporter assay, we undertook a small-molecule high-throughput screening (HTS) of 68, 979 compounds and identified nine compounds that selectively reduced the misfolded P23H rhodopsin without an effect on the wild type (WT) rhodopsin protein. Further, we found five of these compounds, including...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electroretinography
Share to Mutant Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NIH 3T3 Cells

Share to Photoreceptor Cells

Share to Proteasome Endopeptidase Complex

Share to Retina

Share to Retinitis Pigmentosa

Share to Rhodopsin

Source

Open in PubMed Open full text

Identifiers

PMID: 32536017
DOI: 10.1096/fj.202000282R
PMCID: PMC7688577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacological clearance of misfolded rhodopsin for the treatment of RHO-associated retinitis pigmentosa.PMID 32536017Read ↗

The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy.Semantic proximity Read ↗

High-throughput screening assays to identify small molecules preventing photoreceptor degeneration caused by the rhodopsin P23H mutation.Semantic proximity Read ↗

Rhodopsin as a Molecular Target to Mitigate Retinitis Pigmentosa.Semantic proximity Read ↗

Mechanisms of Rhodopsin-Related Inherited Retinal Degeneration and Pharmacological Treatment StrategiesSemantic proximity Read ↗

A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation.Semantic proximity Read ↗

Targeting the Proteostasis Network in Rhodopsin Retinitis Pigmentosa.Semantic proximity Read ↗

Flavonoids improve the stability and function of P23H rhodopsin slowing down the progression of retinitis pigmentosa in mice.Semantic proximity Read ↗

Inhibiting autophagy reduces retinal degeneration caused by protein misfolding.Semantic proximity Read ↗

Pharmacological inhibition of the VCP/proteasome axis rescues photoreceptor degeneration in RHO <sup>P23H</sup> rat retinal explantsSemantic proximity Read ↗

Pharmacological Inhibition of the VCP/Proteasome Axis Rescues Photoreceptor Degeneration in RHOP23H Rat Retinal Explants.Semantic proximity Read ↗

Rhodopsin-associated retinal dystrophy: Disease mechanisms and therapeutic strategiesSemantic proximity Read ↗

Molecular mechanisms of rhodopsin retinitis pigmentosa and the efficacy of pharmacological rescue.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.